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TargetThymidine phosphorylase
LigandBDBM50201013
Substrate/Competitorn/a
Meas. Tech.ChEMBL_422808 (CHEMBL856524)
Ki 1050±n/a nM
Citation Allan, ALGladstone, PLPrice, MLHopkins, SAJuarez, JCDoñate, FTernansky, RJShaw, DEGanem, BLi, YWang, WEalick, S Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase. J Med Chem49:7807-15 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidine phosphorylase
Name:Thymidine phosphorylase
Synonyms:ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase
Type:Enzyme
Mol. Mass.:49948.87
Organism:Homo sapiens (Human)
Description:The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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  Blast E-value cutoff:
BDBM50201013
n/a
NameBDBM50201013
Synonyms:((2S,3aR,4S,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-hexahydrofuro[3,4-b]furan-2-yl)methylphosphonic acid | ((2S,3aR,4S,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexahydrofuro[3,4-b]furan-2-yl)methylphosphonic acid | CHEMBL373989
TypeSmall organic molecule
Emp. Form.C13H19N2O8P
Mol. Mass.362.2723
SMILESCc1cn([C@@H]2O[C@H](CO)[C@H]3C[C@@H](CP(O)(O)=O)O[C@@H]23)c(=O)[nH]c1=O |r|
Structure
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