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TargetMelanin-concentrating hormone receptor 1
LigandBDBM50197113
Substrate/Competitorn/a
Meas. Tech.ChEMBL_421480 (CHEMBL854909)
IC50 4±n/a nM
Citation Souers, AJIyengar, RRJudd, ASBeno, DWGao, JZhao, GBrune, MENapier, JJMulhern, MMLynch, JKFreeman, JCWodka, DChen, CJFalls, HDBrodjian, SDayton, BDDiaz, GJBush, ENShapiro, RDroz, BAKnourek-Segel, VHernandez, LEMarsh, KCReilly, RMSham, HLCollins, CAKym, PR Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines. Bioorg Med Chem Lett17:884-9 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanin-concentrating hormone receptor 1
Name:Melanin-concentrating hormone receptor 1
Synonyms:G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:45976.27
Organism:Homo sapiens (Human)
Description:Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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  Blast E-value cutoff:
BDBM50197113
n/a
NameBDBM50197113
Synonyms:CHEMBL214731 | N-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-yl)-6-fluoro-4-oxo-4H-chromene-2-carboxamide | N-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]-6-fluoro-4-oxo-4H-chromene-2-carboxamide
TypeSmall organic molecule
Emp. Form.C23H21FN2O5
Mol. Mass.424.4216
SMILESFc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1
Structure
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