Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | D(1A) dopamine receptor | ||
Ligand | BDBM50088341 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_453884 (CHEMBL885886) | ||
Ki | 1.9±n/a nM | ||
Citation | Enzensperger, C; Kilian, S; Ackermann, M; Koch, A; Kelch, K; Lehmann, J Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists. Bioorg Med Chem Lett17:1399-402 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
D(1A) dopamine receptor | |||
Name: | D(1A) dopamine receptor | ||
Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A | ||
Type: | Enzyme | ||
Mol. Mass.: | 49303.43 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P21728 | ||
Residue: | 446 | ||
Sequence: |
| ||
BDBM50088341 | |||
n/a | |||
Name | BDBM50088341 | ||
Synonyms: | 11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{15,20}]henicosa-1(14),3(8),4,6,15,17,19-heptaene | 7-Methyl-6,7,8,9,14,15-hexahydro-5H-indolo[3,2-f][3]-benzazecine | 7-methyl-6,7,8,9,14,15-hexahydro-5H-benzo[7,8]azecino[5,4-b]indole(LE 300) | 7-methyl-6,7,8,9,14,15-hexahydro-5H-indolo[3,2-f][3]benzazecine | CHEMBL441618 | LE 300 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H22N2 | ||
Mol. Mass. | 290.4021 | ||
SMILES | CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21 | ||
Structure |