| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase B2 |
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| Ligand | BDBM50201429 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453904 (CHEMBL885908) |
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| IC50 | 165±n/a nM |
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| Citation |  Islam, I; Bryant, J; May, K; Mohan, R; Yuan, S; Kent, L; Morser, J; Zhao, L; Vergona, R; White, K; Adler, M; Whitlow, M; Buckman, BO 3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem Lett17:1349-54 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxypeptidase B2 |
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| Name: | Carboxypeptidase B2 |
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| Synonyms: | CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB |
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| Type: | Enzyme |
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| Mol. Mass.: | 48432.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96IY4 |
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| Residue: | 423 |
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| Sequence: | MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
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| BDBM50201429 |
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| n/a |
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| Name | BDBM50201429 |
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| Synonyms: | 2-(1-carbamimidoylpiperidin-3-yl)-3-mercaptopropanoic acid | CHEMBL245589 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H17N3O2S |
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| Mol. Mass. | 231.315 |
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| SMILES | NC(=N)N1CCCC(C1)C(CS)C(O)=O |w:9.10,7.6| |
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| Structure | 
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