| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase N catalytic chain |
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| Ligand | BDBM50201436 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453906 (CHEMBL885910) |
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| IC50 | 4950±n/a nM |
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| Citation |  Islam, I; Bryant, J; May, K; Mohan, R; Yuan, S; Kent, L; Morser, J; Zhao, L; Vergona, R; White, K; Adler, M; Whitlow, M; Buckman, BO 3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem Lett17:1349-54 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxypeptidase N catalytic chain |
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| Name: | Carboxypeptidase N catalytic chain |
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| Synonyms: | ACBP | Anaphylatoxin inactivator | Arginine carboxypeptidase | CBPN_HUMAN | CPN | CPN1 | Carboxypeptidase N catalytic chain | Carboxypeptidase N polypeptide 1 | Carboxypeptidase N small subunit | Carboxypeptidase N, catalytic subunit | Kininase-1 | Lysine carboxypeptidase | Plasma carboxypeptidase B | SCPN | Serum carboxypeptidase N |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52293.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1496379 |
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| Residue: | 458 |
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| Sequence: | MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHL
YVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQD
TRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPN
HHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRT
ASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHT
NCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVIS
VSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIP
QVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA
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| BDBM50201436 |
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| n/a |
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| Name | BDBM50201436 |
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| Synonyms: | 2-(1-(2-aminoacetyl)piperidin-4-yl)-3-mercaptopropanoic acid | CHEMBL245786 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H18N2O3S |
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| Mol. Mass. | 246.327 |
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| SMILES | NCC(=O)N1CCC(CC1)C(CS)C(O)=O |w:10.11| |
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| Structure | 
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