| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P-selectin |
|---|
| Ligand | BDBM50201927 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_423321 (CHEMBL853739) |
|---|
| IC50 | 6500000±n/a nM |
|---|
| Citation |  Kaila, N; Janz, K; Huang, A; Moretto, A; DeBernardo, S; Bedard, PW; Tam, S; Clerin, V; Keith, JC; Tsao, DH; Sushkova, N; Shaw, GD; Camphausen, RT; Schaub, RG; Wang, Q 2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists. J Med Chem50:40-64 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P-selectin |
|---|
| Name: | P-selectin |
|---|
| Synonyms: | GMRP | GRMP | LYAM3_HUMAN | P-selectin | P-selectin/P-selectin glycoprotein ligand 1 | SELP |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 90834.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1438999 |
|---|
| Residue: | 830 |
|---|
| Sequence: | MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYC
QNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADN
EPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGN
YTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPS
KLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVG
PEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRV
RGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF
MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE
GLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFIC
DEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF
SCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGLQCPALTTPGQGTMYCRHHPG
TFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNL
WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVA
STIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP
|
|
|
|---|
| BDBM50201927 |
|---|
| n/a |
|---|
| Name | BDBM50201927 |
|---|
| Synonyms: | 3-hydroxy-2-phenylquinoline-4-carboxylic acid | CHEMBL219376 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H11NO3 |
|---|
| Mol. Mass. | 265.2634 |
|---|
| SMILES | OC(=O)c1c(O)c(nc2ccccc12)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
