| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 1 |
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| Ligand | BDBM50202084 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_423382 (CHEMBL909901) |
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| IC50 | 28±n/a nM |
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| Citation |  Clasby, MC; Chackalamannil, S; Czarniecki, M; Doller, D; Eagen, K; Greenlee, W; Kao, G; Lin, Y; Tsai, H; Xia, Y; Ahn, HS; Agans-Fantuzzi, J; Boykow, G; Chintala, M; Foster, C; Smith-Torhan, A; Alton, K; Bryant, M; Hsieh, Y; Lau, J; Palamanda, J Metabolism-based identification of a potent thrombin receptor antagonist. J Med Chem50:129-38 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 1 |
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| Name: | Proteinase-activated receptor 1 |
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| Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
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| Type: | Protein |
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| Mol. Mass.: | 47450.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25116 |
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| Residue: | 425 |
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| Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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| BDBM50202084 |
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| n/a |
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| Name | BDBM50202084 |
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| Synonyms: | (3R,3aS,4S,4aR,8aR,9aR)-7,7-difluoro-decahydro-3-methyl-4-[(E)-2-[ 5-(2-fluorophenyl)-2-pyridinyl] ethenyl]naphtho[2,3-c]furan-1(3H)-one | CHEMBL217958 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26F3NO2 |
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| Mol. Mass. | 441.4853 |
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| SMILES | C[C@H]1OC(=O)[C@@H]2C[C@@H]3CC(F)(F)CC[C@H]3[C@H](\C=C\c3ccc(cn3)-c3ccccc3F)[C@H]12 |r| |
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| Structure | 
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