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TargetBradykinin B1 receptor
LigandBDBM50202426
Substrate/Competitorn/a
Meas. Tech.ChEMBL_423668
Ki 0.81±n/a nM
Citation Kuduk SDDi Marco CNChang RKWood MRSchirripa KMKim JJWai JMDiPardo RMMurphy KLRansom RWHarrell CMReiss DRHolahan MACook JHess JFSain NUrban MOTang CPrueksaritanont TPettibone DJBock MG Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists. J Med Chem 50:272-82 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bradykinin B1 receptor
Name:Bradykinin B1 receptor
Synonyms:B1 BRADYKININ | B1 bradykinin receptor | B1R | BK-1 receptor
Type:Enzyme
Mol. Mass.:40508.87
Organism:Homo sapiens (Human)
Description:P46663
Residue:353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50202426
n/a
NameBDBM50202426
Synonyms:3,3'-difluoro-4'-({[1-(3,3,3-trifluoro-propionylamino)-cyclopropanecarbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid methyl ester | CHEMBL219083
TypeSmall organic molecule
Emp. Form.C22H19F5N2O4
Mol. Mass.470.3893
SMILESCOC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(CC2)NC(=O)CC(F)(F)F)c(F)c1
Structure
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