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TargetTyrosine-protein kinase Fgr
LigandBDBM50202734
Substrate/Competitorn/a
Meas. Tech.ChEMBL_446811 (CHEMBL897110)
IC50 14100±n/a nM
Citation Abbott, LBetschmann, PBurchat, ACalderwood, DJDavis, HHrnciar, PHirst, GCLi, BMorytko, MMullen, KYang, B Discovery of thienopyridines as Src-family selective Lck inhibitors. Bioorg Med Chem Lett17:1167-71 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Fgr
Name:Tyrosine-protein kinase Fgr
Synonyms:FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr
Type:protein
Mol. Mass.:59469.88
Organism:Homo sapiens (Human)
Description:P09769
Residue:529
Sequence:
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50202734
n/a
NameBDBM50202734
Synonyms:CHEMBL232542 | N-(4-(4-amino-7-(3-(diethylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide
TypeSmall organic molecule
Emp. Form.C31H33N5O2S
Mol. Mass.539.691
SMILESCCN(CC)C\C=C\c1cnc(N)c2c(csc12)-c1ccc(NC(=O)c2cc3ccccc3n2C)c(OC)c1
Structure
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