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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Fgr | ||
| Ligand | BDBM50202735 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_446811 (CHEMBL897110) | ||
| IC50 | 21700±n/a nM | ||
| Citation |  Abbott, L; Betschmann, P; Burchat, A; Calderwood, DJ; Davis, H; Hrnciar, P; Hirst, GC; Li, B; Morytko, M; Mullen, K; Yang, B Discovery of thienopyridines as Src-family selective Lck inhibitors. Bioorg Med Chem Lett17:1167-71 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Fgr | |||
| Name: | Tyrosine-protein kinase Fgr | ||
| Synonyms: | FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr | ||
| Type: | protein | ||
| Mol. Mass.: | 59469.88 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P09769 | ||
| Residue: | 529 | ||
| Sequence: |
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| BDBM50202735 | |||
| n/a | |||
| Name | BDBM50202735 | ||
| Synonyms: | CHEMBL395666 | N-(4-(4-amino-7-(3-((1s,4s)-4-aminocyclohexylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H36N6O2S | ||
| Mol. Mass. | 580.743 | ||
| SMILES | COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(\C=C\CN[C@@H]3CC[C@H](N)CC3)cnc(N)c12 |wU:30.32,33.36,(28.87,-24.7,;27.4,-24.22,;26.26,-25.25,;24.79,-24.77,;23.65,-25.8,;23.98,-27.31,;25.43,-27.78,;26.58,-26.75,;28.03,-27.23,;28.36,-28.73,;27.21,-29.77,;29.82,-29.21,;30.29,-30.69,;31.84,-30.68,;32.87,-31.82,;34.38,-31.5,;34.86,-30.04,;33.82,-28.89,;32.32,-29.21,;31.08,-28.3,;31.08,-26.76,;22.18,-25.32,;20.94,-26.24,;19.69,-25.33,;20.17,-23.87,;19.4,-22.55,;17.86,-22.55,;17.09,-21.22,;15.55,-21.23,;14.78,-19.89,;15.54,-18.56,;17.09,-18.56,;17.85,-17.23,;17.09,-15.9,;17.86,-14.57,;15.55,-15.9,;14.78,-17.23,;20.16,-21.22,;21.7,-21.22,;22.47,-22.55,;24.01,-22.55,;21.7,-23.87,)| | ||
| Structure | 
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