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TargetBDKRB2
LigandBDBM50203210
Substrate/Competitorn/a
Meas. Tech.ChEMBL_425212
Ki 16000±n/a nM
Citation D'Amico DCAya THuman JFotsch CChen JJBiswas KRiahi BNorman MHWilloughby CAHungate RReider PJBiddlecome GLester-Zeiner DStaden CVJohnson EKamassah AArik LWang JViswanadhan VNGroneberg RDZhan JSuzuki HToro AMareska DAClarke DEHarvey DMBurgess LELaird ERAskew BNg G Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity. J Med Chem 50:607-10 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
BDKRB2
Name:Bradykinin B2 receptor
Synonyms:B2 BRADYKININ | B2 bradykinin receptor | B2R | BK-2 receptor | Bradykinin B2 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:44467.17
Organism:Homo sapiens (Human)
Description:B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
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  Blast E-value cutoff:
BDBM50203210
n/a
NameBDBM50203210
Synonyms:(R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-7-(piperidin-1-ylmethyl)-2,2-dioxo-1,2,3,4-tetrahydro-1-methyl-2,1-benzothiazine-4-yl)propanamide | CHEMBL412552
TypeSmall organic molecule
Emp. Form.C34H38N4O5S2
Mol. Mass.646.819
SMILESCN1c2cc(CN3CCCCC3)ccc2[C@@H](CS1(=O)=O)NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1
Structure
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