| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50160100 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_454342 (CHEMBL903520) |
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| IC50 | 1.3±n/a nM |
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| Citation |  Madsen-Duggan, CB; Debenham, JS; Walsh, TF; Toupence, RB; Huang, SX; Wang, J; Tong, X; Lao, J; Fong, TM; Schaeffer, MT; Xiao, JC; Huang, CR; Shen, CP; Stribling, DS; Shearman, LP; Strack, AM; MacIntyre, DE; Van der Ploeg, LH; Goulet, MT Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists. Bioorg Med Chem Lett17:2031-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52868.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21554 |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50160100 |
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| n/a |
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| Name | BDBM50160100 |
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| Synonyms: | 2-(3,4-difluorobenzyloxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)nicotinonitrile | 5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(3,4-difluoro-benzyloxy)-nicotinonitrile | CHEMBL367819 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H13Cl3F2N2O |
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| Mol. Mass. | 501.739 |
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| SMILES | Fc1ccc(COc2nc(-c3ccc(Cl)cc3Cl)c(cc2C#N)-c2ccc(Cl)cc2)cc1F |
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| Structure | 
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