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TargetDisintegrin and metalloproteinase domain-containing protein 17
LigandBDBM50204404
Substrate/Competitorn/a
Meas. Tech.ChEMBL_447058 (CHEMBL897359)
IC50<1±n/a nM
Citation Chen, XTGhavimi, BCorbett, RLXue, CBLiu, RQCovington, MBQian, MVaddi, KGChrist, DDHartman, KDRibadeneira, MDTrzaskos, JMNewton, RCDecicco, CPDuan, JJ A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors. Bioorg Med Chem Lett17:1865-70 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Disintegrin and metalloproteinase domain-containing protein 17
Name:Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:Metalloprotease
Mol. Mass.:12197.99
Organism:Sus scrofa (pig)
Description:Partially purified TACE was obtained from porcine spleen.
Residue:112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGK
KNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
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  Blast E-value cutoff:
BDBM50204404
n/a
NameBDBM50204404
Synonyms:(3S,4S)-tert-butyl 3-(hydroxycarbamoyl)-4-(4-((2-methylquinolin-4-yl)methyl)benzamido)pyrrolidine-1-carboxylate | CHEMBL399604
TypeSmall organic molecule
Emp. Form.C28H32N4O5
Mol. Mass.504.5775
SMILESCc1cc(Cc2ccc(cc2)C(=O)N[C@@H]2CN(C[C@@H]2C(=O)NO)C(=O)OC(C)(C)C)c2ccccc2n1
Structure
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