Reaction Details |
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Target | Disintegrin and metalloproteinase domain-containing protein 17 |
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Ligand | BDBM50204412 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_447058 (CHEMBL897359) |
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IC50 | 1.3±n/a nM |
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Citation | Chen, XT; Ghavimi, B; Corbett, RL; Xue, CB; Liu, RQ; Covington, MB; Qian, M; Vaddi, KG; Christ, DD; Hartman, KD; Ribadeneira, MD; Trzaskos, JM; Newton, RC; Decicco, CP; Duan, JJ A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors. Bioorg Med Chem Lett17:1865-70 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Disintegrin and metalloproteinase domain-containing protein 17 |
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Name: | Disintegrin and metalloproteinase domain-containing protein 17 |
Synonyms: | A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme |
Type: | Metalloprotease |
Mol. Mass.: | 12197.99 |
Organism: | Sus scrofa (pig) |
Description: | Partially purified TACE was obtained from porcine spleen. |
Residue: | 112 |
Sequence: | MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGK
KNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
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BDBM50204412 |
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n/a |
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Name | BDBM50204412 |
Synonyms: | (3R,4R)-4-(4-((2-cyclopropylquinolin-4-yl)methyl)benzamido)-N-hydroxy-tetrahydro-2H-pyran-3-carboxamide | CHEMBL234416 |
Type | Small organic molecule |
Emp. Form. | C26H27N3O4 |
Mol. Mass. | 445.5103 |
SMILES | ONC(=O)[C@H]1COCC[C@H]1NC(=O)c1ccc(Cc2cc(nc3ccccc23)C2CC2)cc1 |
Structure |
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