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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk1 | ||
| Ligand | BDBM50204726 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_442099 (CHEMBL891237) | ||
| IC50 | 6472±n/a nM | ||
| Citation |  Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk1 | |||
| Name: | Serine/threonine-protein kinase Chk1 | ||
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 54443.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_166295192 | ||
| Residue: | 476 | ||
| Sequence: |
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| BDBM50204726 | |||
| n/a | |||
| Name | BDBM50204726 | ||
| Synonyms: | 2-(4-(6-(((1s,4s)-4-methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenyl)acetic acid | CHEMBL438329 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H29N3O2 | ||
| Mol. Mass. | 415.5274 | ||
| SMILES | C[C@H]1CC[C@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(CC(O)=O)cc2)c1 |wU:4.7,1.0,(-8.65,-36.79,;-7.31,-36.02,;-7.29,-34.48,;-5.97,-33.72,;-4.64,-34.5,;-4.65,-36.03,;-5.98,-36.79,;-3.3,-33.73,;-1.98,-34.5,;-.64,-33.73,;-.63,-32.19,;.69,-31.42,;2.02,-32.18,;2.03,-33.73,;3.5,-34.21,;4.41,-32.97,;5.89,-32.48,;5.89,-30.93,;4.41,-30.45,;3.5,-31.7,;7.14,-33.38,;6.98,-34.92,;8.21,-35.82,;9.62,-35.2,;10.87,-36.09,;12.27,-35.46,;13.52,-36.36,;12.42,-33.93,;9.78,-33.66,;8.53,-32.76,;.7,-34.5,)| | ||
| Structure | 
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