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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk1 | ||
| Ligand | BDBM50204717 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_442099 (CHEMBL891237) | ||
| IC50 | 1880±n/a nM | ||
| Citation |  Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk1 | |||
| Name: | Serine/threonine-protein kinase Chk1 | ||
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 54443.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_166295192 | ||
| Residue: | 476 | ||
| Sequence: |
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| BDBM50204717 | |||
| n/a | |||
| Name | BDBM50204717 | ||
| Synonyms: | 2-(4-(6-(((1s,4s)-4-methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenyl)acetonitrile | CHEMBL242324 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28N4 | ||
| Mol. Mass. | 396.5273 | ||
| SMILES | C[C@H]1CC[C@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(CC#N)cc2)c1 |wU:4.7,1.0,(20.38,-23.67,;21.71,-22.91,;21.73,-21.37,;23.05,-20.61,;24.39,-21.39,;24.38,-22.92,;23.05,-23.67,;25.72,-20.62,;27.05,-21.39,;28.38,-20.62,;28.39,-19.07,;29.71,-18.31,;31.05,-19.07,;31.05,-20.62,;32.52,-21.1,;33.44,-19.85,;34.91,-19.37,;34.92,-17.82,;33.43,-17.34,;32.52,-18.59,;36.16,-20.27,;36,-21.8,;37.24,-22.71,;38.64,-22.08,;39.89,-22.98,;41.29,-22.35,;42.69,-21.72,;38.8,-20.55,;37.55,-19.65,;29.72,-21.39,)| | ||
| Structure | 
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