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TargetSerine/threonine-protein kinase Chk1
LigandBDBM50204713
Substrate/Competitorn/a
Meas. Tech.ChEMBL_442099 (CHEMBL891237)
IC50 8742±n/a nM
Citation Tong, YClaiborne, AStewart, KDPark, CKovar, PChen, ZCredo, RBGu, WZGwaltney, SLJudge, RAZhang, HRosenberg, SHSham, HLSowin, TJLin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Chk1
Name:Serine/threonine-protein kinase Chk1
Synonyms:CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:54443.02
Organism:Homo sapiens (Human)
Description:gi_166295192
Residue:476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50204713
n/a
NameBDBM50204713
Synonyms:CHEMBL390627 | N-(2-hydroxyethyl)-4-(6-(((1r,4r)-4-methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzenesulfonamide
TypeSmall organic molecule
Emp. Form.C26H32N4O3S
Mol. Mass.480.622
SMILESC[C@H]1CC[C@@H](CC1)NCc1ccc-2c(Cc3c-2n[nH]c3-c2ccc(cc2)S(=O)(=O)NCCO)c1 |wU:4.7,wD:1.0,(16.56,-3.78,;17.89,-3.01,;19.22,-3.78,;20.56,-3.02,;20.57,-1.49,;19.22,-.72,;17.9,-1.48,;21.9,-.72,;23.23,-1.49,;24.56,-.72,;24.56,.82,;25.89,1.59,;27.23,.83,;27.23,-.73,;28.7,-1.2,;29.61,.04,;28.7,1.31,;29.61,2.56,;31.1,2.08,;31.09,.53,;32.33,-.38,;32.17,-1.91,;33.41,-2.82,;34.82,-2.19,;34.98,-.65,;33.73,.24,;36.06,-3.09,;35.16,-4.34,;36.97,-1.85,;37.3,-4,;38.71,-3.37,;39.95,-4.28,;41.36,-3.65,;25.89,-1.5,)|
Structure
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