Reaction Details | |||
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Target | Serine/threonine-protein kinase Chk1 | ||
Ligand | BDBM50204708 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_442099 (CHEMBL891237) | ||
IC50 | 1600±n/a nM | ||
Citation | Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase Chk1 | |||
Name: | Serine/threonine-protein kinase Chk1 | ||
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 54443.02 | ||
Organism: | Homo sapiens (Human) | ||
Description: | gi_166295192 | ||
Residue: | 476 | ||
Sequence: |
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BDBM50204708 | |||
n/a | |||
Name | BDBM50204708 | ||
Synonyms: | (1r,4r)-N-((3-(4-ethoxyphenyl)-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl)-4-methylcyclohexanamine | CHEMBL243818 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H31N3O | ||
Mol. Mass. | 401.5438 | ||
SMILES | CCOc1ccc(cc1)-c1n[nH]c-2c1Cc1cc(CN[C@H]3CC[C@H](C)CC3)ccc-21 |wU:20.21,wD:23.25,(13.23,-40.56,;11.98,-39.65,;10.58,-40.28,;9.33,-39.37,;7.92,-40,;6.68,-39.09,;6.85,-37.56,;8.25,-36.94,;9.49,-37.83,;5.61,-36.66,;5.61,-35.1,;4.13,-34.62,;3.21,-35.88,;4.12,-37.14,;3.21,-38.39,;1.74,-37.91,;.4,-38.68,;-.93,-37.91,;-2.26,-38.67,;-3.6,-37.9,;-4.93,-38.67,;-4.93,-40.21,;-6.27,-40.97,;-7.61,-40.2,;-8.94,-40.96,;-7.6,-38.66,;-6.27,-37.9,;-.93,-36.36,;.4,-35.59,;1.74,-36.36,)| | ||
Structure |