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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Androgen receptor | ||
| Ligand | BDBM18171 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_438312 (CHEMBL887414) | ||
| EC50 | 2.3±n/a nM | ||
| Citation |  Hamann, LG; Manfredi, MC; Sun, C; Krystek, SR; Huang, Y; Bi, Y; Augeri, DJ; Wang, T; Zou, Y; Betebenner, DA; Fura, A; Seethala, R; Golla, R; Kuhns, JE; Lupisella, JA; Darienzo, CJ; Custer, LL; Price, JL; Johnson, JM; Biller, SA; Zahler, R; Ostrowski, J Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators. Bioorg Med Chem Lett17:1860-4 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Androgen receptor | |||
| Name: | Androgen receptor | ||
| Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 | ||
| Type: | Receptor | ||
| Mol. Mass.: | 99185.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | CHO cells were stably transfected with human AR gene. | ||
| Residue: | 920 | ||
| Sequence: |
| ||
| BDBM18171 | |||
| n/a | |||
| Name | BDBM18171 | ||
| Synonyms: | 4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]naphthalene-1-carbonitrile | CHEMBL425646 | N-aryl-bicyclic hydantoin, (-)10b | hydantoin, 7 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H13N3O3 | ||
| Mol. Mass. | 307.3034 | ||
| SMILES | O[C@@H]1CCn2c1c(O)n(-c1ccc(C#N)c3ccccc13)c2=O |r,wU:1.0,(-7.31,4.33,;-6.4,3.09,;-6.88,1.62,;-5.63,.72,;-4.39,1.62,;-4.86,3.09,;-3.62,3.99,;-3.62,5.53,;-2.37,3.09,;-.83,3.09,;.03,4.36,;1.57,4.25,;2.24,2.87,;3.78,2.76,;5.32,2.76,;1.38,1.59,;2.05,.21,;1.19,-1.07,;-.35,-.96,;-1.02,.43,;-.16,1.7,;-2.85,1.62,;-1.94,.38,)| | ||
| Structure | 
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