Reaction Details |
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Target | Prostaglandin D2 receptor |
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Ligand | BDBM50184217 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_425870 (CHEMBL856874) |
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Ki | 1.8±n/a nM |
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Citation | Sturino, CF; O'Neill, G; Lachance, N; Boyd, M; Berthelette, C; Labelle, M; Li, L; Roy, B; Scheigetz, J; Tsou, N; Aubin, Y; Bateman, KP; Chauret, N; Day, SH; Lévesque, JF; Seto, C; Silva, JH; Trimble, LA; Carriere, MC; Denis, D; Greig, G; Kargman, S; Lamontagne, S; Mathieu, MC; Sawyer, N; Slipetz, D; Abraham, WM; Jones, T; McAuliffe, M; Piechuta, H; Nicoll-Griffith, DA; Wang, Z; Zamboni, R; Young, RN; Metters, KM Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J Med Chem50:794-806 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin D2 receptor |
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Name: | Prostaglandin D2 receptor |
Synonyms: | PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor |
Type: | Enzyme |
Mol. Mass.: | 40288.87 |
Organism: | Homo sapiens (Human) |
Description: | Q13258 |
Residue: | 359 |
Sequence: | MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV
FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST
LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG
TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT
RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS
EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
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BDBM50184217 |
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n/a |
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Name | BDBM50184217 |
Synonyms: | 2-((R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid | CHEMBL207203 | [(3R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid |
Type | Small organic molecule |
Emp. Form. | C23H24ClNO5S |
Mol. Mass. | 461.958 |
SMILES | CC(O)c1cc(cc2c3CC[C@H](CC(O)=O)c3n(Cc3ccc(Cl)cc3)c12)S(C)(=O)=O |
Structure |
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