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TargetProstaglandin D2 receptor
LigandBDBM50184217
Substrate/Competitorn/a
Meas. Tech.ChEMBL_425870 (CHEMBL856874)
Ki 1.8±n/a nM
Citation Sturino, CFO'Neill, GLachance, NBoyd, MBerthelette, CLabelle, MLi, LRoy, BScheigetz, JTsou, NAubin, YBateman, KPChauret, NDay, SHLévesque, JFSeto, CSilva, JHTrimble, LACarriere, MCDenis, DGreig, GKargman, SLamontagne, SMathieu, MCSawyer, NSlipetz, DAbraham, WMJones, TMcAuliffe, MPiechuta, HNicoll-Griffith, DAWang, ZZamboni, RYoung, RNMetters, KM Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J Med Chem50:794-806 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor
Name:Prostaglandin D2 receptor
Synonyms:PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor
Type:Enzyme
Mol. Mass.:40288.87
Organism:Homo sapiens (Human)
Description:Q13258
Residue:359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV
FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST
LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG
TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT
RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS
EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50184217
n/a
NameBDBM50184217
Synonyms:2-((R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid | CHEMBL207203 | [(3R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
TypeSmall organic molecule
Emp. Form.C23H24ClNO5S
Mol. Mass.461.958
SMILESCC(O)c1cc(cc2c3CC[C@H](CC(O)=O)c3n(Cc3ccc(Cl)cc3)c12)S(C)(=O)=O
Structure
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