| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytosolic phospholipase A2 |
|---|
| Ligand | BDBM50205532 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_428330 (CHEMBL917108) |
|---|
| IC50 | 120±n/a nM |
|---|
| Citation |  Lee, KL; Foley, MA; Chen, L; Behnke, ML; Lovering, FE; Kirincich, SJ; Wang, W; Shim, J; Tam, S; Shen, MW; Khor, S; Xu, X; Goodwin, DG; Ramarao, MK; Nickerson-Nutter, C; Donahue, F; Ku, MS; Clark, JD; McKew, JC Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. J Med Chem50:1380-400 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytosolic phospholipase A2 |
|---|
| Name: | Cytosolic phospholipase A2 |
|---|
| Synonyms: | CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 85219.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P47712 |
|---|
| Residue: | 749 |
|---|
| Sequence: | MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
|
|
|
|---|
| BDBM50205532 |
|---|
| n/a |
|---|
| Name | BDBM50205532 |
|---|
| Synonyms: | 4-{2-[1-benzhydryl-5-nitro-2-(3-phenylmethanesulfonyl-propyl)-1H-indol-3-yl]-ethoxy}-benzoic acid | CHEMBL220736 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C39H35N3O7S |
|---|
| Mol. Mass. | 689.776 |
|---|
| SMILES | OC(=O)c1ccc(OCCc2c(CCNS(=O)(=O)Cc3ccccc3)n(C(c3ccccc3)c3ccccc3)c3ccc(cc23)[N+]([O-])=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
