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TargetCytosolic phospholipase A2
LigandBDBM50205516
Substrate/Competitorn/a
Meas. Tech.ChEMBL_428330 (CHEMBL917108)
IC50 100±n/a nM
Citation Lee, KLFoley, MAChen, LBehnke, MLLovering, FEKirincich, SJWang, WShim, JTam, SShen, MWKhor, SXu, XGoodwin, DGRamarao, MKNickerson-Nutter, CDonahue, FKu, MSClark, JDMcKew, JC Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. J Med Chem50:1380-400 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytosolic phospholipase A2
Name:Cytosolic phospholipase A2
Synonyms:CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA
Type:Protein
Mol. Mass.:85219.30
Organism:Homo sapiens (Human)
Description:P47712
Residue:749
Sequence:
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
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  Blast E-value cutoff:
BDBM50205516
n/a
NameBDBM50205516
Synonyms:4-{2-[5-chloro-2-(2-{[(2,4-dichlorobenzyl)sulfonyl]amino}-ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoic acid | CHEMBL375593
TypeSmall organic molecule
Emp. Form.C39H33Cl3N2O5S
Mol. Mass.748.114
SMILESOC(=O)c1ccc(OCCc2c(CCNS(=O)(=O)Cc3ccc(Cl)cc3Cl)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Structure
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