Reaction Details |
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Target | 5-hydroxytryptamine receptor 2B |
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Ligand | BDBM50001915 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_428465 (CHEMBL918966) |
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Ki | 24±n/a nM |
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Citation | Wacker, DA; Varnes, JG; Malmstrom, SE; Cao, X; Hung, CP; Ung, T; Wu, G; Zhang, G; Zuvich, E; Thomas, MA; Keim, WJ; Cullen, MJ; Rohrbach, KW; Qu, Q; Narayanan, R; Rossi, K; Janovitz, E; Lehman-McKeeman, L; Malley, MF; Devenny, J; Pelleymounter, MA; Miller, KJ; Robl, JA Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor. J Med Chem50:1365-79 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2B |
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Name: | 5-hydroxytryptamine receptor 2B |
Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 54312.47 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
Residue: | 481 |
Sequence: | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
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BDBM50001915 |
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n/a |
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Name | BDBM50001915 |
Synonyms: | 1-(3-chlorophenyl)piperazine | CHEMBL478 | m-Chlorophenylpiperazine | mCPP |
Type | Small organic molecule |
Emp. Form. | C10H13ClN2 |
Mol. Mass. | 196.677 |
SMILES | Clc1cccc(c1)N1CCNCC1 |
Structure |
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