Reaction Details |
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Target | 5-hydroxytryptamine receptor 2C |
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Ligand | BDBM50205856 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_428466 (CHEMBL918967) |
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Ki | 35±n/a nM |
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Citation | Wacker, DA; Varnes, JG; Malmstrom, SE; Cao, X; Hung, CP; Ung, T; Wu, G; Zhang, G; Zuvich, E; Thomas, MA; Keim, WJ; Cullen, MJ; Rohrbach, KW; Qu, Q; Narayanan, R; Rossi, K; Janovitz, E; Lehman-McKeeman, L; Malley, MF; Devenny, J; Pelleymounter, MA; Miller, KJ; Robl, JA Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor. J Med Chem50:1365-79 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2C |
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Name: | 5-hydroxytryptamine receptor 2C |
Synonyms: | 5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 51836.79 |
Organism: | Homo sapiens (Human) |
Description: | P28335 |
Residue: | 458 |
Sequence: | MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
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BDBM50205856 |
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n/a |
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Name | BDBM50205856 |
Synonyms: | (R)-9-cyclopropyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one | CHEMBL375170 |
Type | Small organic molecule |
Emp. Form. | C15H15F3N2O |
Mol. Mass. | 296.2876 |
SMILES | FC(F)(F)c1cc(cc2[C@@H]3CNCCN3C(=O)c12)C1CC1 |
Structure |
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