Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50206652 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_438449 (CHEMBL887549) |
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Ki | 6900±n/a nM |
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Citation | Lee, YS; Nyberg, J; Moye, S; Agnes, RS; Davis, P; Ma, SW; Lai, J; Porreca, F; Vardanyan, R; Hruby, VJ Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorg Med Chem Lett17:2161-5 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50206652 |
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n/a |
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Name | BDBM50206652 |
Synonyms: | (R)-N-(1-(2-amino-3-(4-chlorophenyl)propanoyl)piperidin-4-yl)-N-phenylpropionamide | CHEMBL231353 |
Type | Small organic molecule |
Emp. Form. | C23H28ClN3O2 |
Mol. Mass. | 413.94 |
SMILES | CCC(=O)N(C1CCN(CC1)C(=O)[C@H](N)Cc1ccc(Cl)cc1)c1ccccc1 |
Structure |
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