| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50206691 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_442721 (CHEMBL892889) |
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| Ki | 80±n/a nM |
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| Citation |  Zhang, M; Tamiya, J; Nguyen, L; Rowbottom, MW; Dyck, B; Vickers, TD; Grey, J; Schwarz, DA; Heise, CE; Haelewyn, J; Mistry, MS; Goodfellow, VS Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists. Bioorg Med Chem Lett17:2535-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50206691 |
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| n/a |
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| Name | BDBM50206691 |
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| Synonyms: | (S)-3-[6-(4-chloro-phenyl)-4-oxo-4H-thieno[3,2-d]pyrimidin-3-yl]-pyrrolidine-1-carboxylic acid methyl-{(S)-1-[2-oxo-2-(4-trifluoromethoxy-phenyl)-ethyl]-pyrrolidin-3-yl}-amide | CHEMBL445407 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H29ClF3N5O4S |
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| Mol. Mass. | 660.106 |
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| SMILES | CN([C@H]1CCN(CC(=O)c2ccc(OC(F)(F)F)cc2)C1)C(=O)N1CC[C@@H](C1)n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 |
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| Structure | 
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