| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 1 |
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| Ligand | BDBM50207583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_443066 (CHEMBL892197) |
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| IC50 | 4.05±n/a nM |
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| Citation |  Zhang, R; Lei, L; Xu, YG; Hua, WY; Gong, GQ Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury. Bioorg Med Chem Lett17:2430-3 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/hydrogen exchanger 1 |
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| Name: | Sodium/hydrogen exchanger 1 |
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| Synonyms: | NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91655.00 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_862370 |
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| Residue: | 820 |
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| Sequence: | MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGD
VTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMK
IGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYF
LPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISA
VDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFL
SFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMAL
IASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVIS
TLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPM
CDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIED
ICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGK
IPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVA
DPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPV
ITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTD
DVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
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| BDBM50207583 |
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| n/a |
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| Name | BDBM50207583 |
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| Synonyms: | CHEMBL234279 | N-[2-(5-nitro-1H-benzoimidazol-2-yl)-benzoyl]-guanidine |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N6O3 |
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| Mol. Mass. | 324.2942 |
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| SMILES | NC(=N)NC(=O)c1ccccc1-c1nc2ccc(cc2[nH]1)[N+]([O-])=O |
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| Structure | 
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