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TargetGlycylpeptide N-tetradecanoyltransferase
LigandBDBM50121716
Substrate/Competitorn/a
Meas. Tech.ChEMBL_458963 (CHEMBL925057)
IC50 0.39±n/a nM
Citation Sheng, CZhu, JZhang, WZhang, MJi, HSong, YXu, HYao, JMiao, ZZhou, YZhu, JLü, J 3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N-myristoyltransferase inhibitors. Eur J Med Chem42:477-86 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycylpeptide N-tetradecanoyltransferase
Name:Glycylpeptide N-tetradecanoyltransferase
Synonyms:2.3.1.97 | Glycylpeptide N-tetradecanoyltransferase | Myristoyl-CoA:protein N-myristoyltransferase | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D110A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D112A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D412A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F115A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F117A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F240A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F339A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F339S)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt G413A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt H227A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt I111A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt I352A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L350V)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L451A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L451Q)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt N175A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt P229A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt S241A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt T114A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt T211A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt V108A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt W232A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y107A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y119A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y225A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y256A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y354A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | NMT | NMT1 | NMT_CANAL | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:Enzyme
Mol. Mass.:51875.96
Organism:Candida albicans (Yeast)
Description:P30418
Residue:451
Sequence:
MSGDNTGNKSNSAPSKSIEELLKLLAMGQELSPAQQKEMKDYKFWKTQPVPSLSETVTEE
GPIDKLKTPEDVPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYS
HEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIH
KKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGF
SHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEF
KHWMLGHDENSDSNVVKSYVVEDENGVITDYFSYYLLPFTVLDNAQHDELGIAYLFYYAS
DSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLF
NYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL
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  Blast E-value cutoff:
BDBM50121716
n/a
NameBDBM50121716
Synonyms:(3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)benzofuran-2-yl)(5-methylpyridin-2-yl)methanone | (5-Methyl-pyridin-2-yl)-(3-methyl-4-{3-[(pyridin-3-ylmethyl)-amino]-propoxy}-benzofuran-2-yl)-methanone | CHEMBL170807
TypeSmall organic molecule
Emp. Form.C25H25N3O3
Mol. Mass.415.4843
SMILESCc1c(oc2cccc(OCCCNCc3cccnc3)c12)C(=O)c1ccc(C)cn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: