Reaction Details |
| Report a problem with these data |
Target | Muscarinic acetylcholine receptor M3 |
---|
Ligand | BDBM50207999 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_429171 (CHEMBL914427) |
---|
Ki | 6.59±n/a nM |
---|
Citation | Peretto, I; Forlani, R; Fossati, C; Giardina, GA; Giardini, A; Guala, M; La Porta, E; Petrillo, P; Radaelli, S; Radice, L; Raveglia, LF; Santoro, E; Scudellaro, R; Scarpitta, F; Bigogno, C; Misiano, P; Dondio, GM; Rizzi, A; Armani, E; Amari, G; Civelli, M; Villetti, G; Patacchini, R; Bergamaschi, M; Delcanale, M; Salcedo, C; Fernández, AG; Imbimbo, BP Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1). J Med Chem50:1571-83 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Muscarinic acetylcholine receptor M3 |
---|
Name: | Muscarinic acetylcholine receptor M3 |
Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 |
Type: | Enzyme |
Mol. Mass.: | 66151.03 |
Organism: | Homo sapiens (Human) |
Description: | P20309 |
Residue: | 590 |
Sequence: | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
|
|
|
BDBM50207999 |
---|
n/a |
---|
Name | BDBM50207999 |
Synonyms: | 3-(1-(3-chlorobenzyl)-piperidin-4-yl)-5-phenyl-5-cyclohexyl-imidazolidin-2-one | CHEMBL222207 |
Type | Small organic molecule |
Emp. Form. | C27H34ClN3O |
Mol. Mass. | 452.031 |
SMILES | Clc1cccc(CN2CCC(CC2)N2CC(NC2=O)(C2CCCCC2)c2ccccc2)c1 |
Structure |
|