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TargetChymase
LigandBDBM50208222
Substrate/Competitorn/a
Meas. Tech.ChEMBL_429291
Ki 11±n/a nM
Citation Greco MNHawkins MJPowell ETAlmond HRde Garavilla LHall JMinor LKWang YCorcoran TWDi Cera ECantwell AMSavvides SNDamiano BPMaryanoff BE Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem 50:1727-30 (2007) [PubMed]  Article
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Chymase
Name:Chymase
Synonyms:Alpha-chymase | Chymase precursor | Mast cell protease I
Type:Enzyme
Mol. Mass.:27340.12
Organism:Homo sapiens (Human)
Description:n/a
Residue:247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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  Blast E-value cutoff:
BDBM50208222
n/a
NameBDBM50208222
Synonyms:(E)-2-(3-chloro-5-fluorostyrylamino)-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxoethyl(methyl)phosphinic acid | CHEMBL374504
TypeSmall organic molecule
Emp. Form.C19H15Cl2FNO3PS
Mol. Mass.458.27
SMILESCP(O)(=O)C(C(=O)NC=Cc1cc(F)cc(Cl)c1)c1csc2ccc(Cl)cc12 |w:9.9|
Structure
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