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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
LigandBDBM50209515
Substrate/Competitorn/a
Meas. Tech.ChEMBL_455270 (CHEMBL886046)
IC50 100±n/a nM
Citation Cantin, LDMagnuson, SGunn, DBarucci, NBreuhaus, MBullock, WHBurke, JClaus, THDaly, MDecarr, LGore-Willse, AHoover-Litty, HKumarasinghe, ESLi, YLiang, SXLivingston, JNLowinger, TMacdougall, MOgutu, HOOlague, AOtt-Morgan, RSchoenleber, RWTersteegen, AWickens, PZhang, ZZhu, JZhu, LSweet, LJ PDE-10A inhibitors as insulin secretagogues. Bioorg Med Chem Lett17:2869-73 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Name:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Synonyms:3',5'-cyclic phosphodiesterase | PDE10A | PDE10_HUMAN | Phosphodiesterase 10 (PDE10) | Phosphodiesterase 10A
Type:Protein
Mol. Mass.:88412.52
Organism:Homo sapiens (Human)
Description:Q9Y233
Residue:779
Sequence:
MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAP
KEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC
NNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLE
SGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVC
RGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELY
SDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYT
GYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHR
IRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIF
VYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTD
LERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNI
FSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMM
TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY
NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
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  Blast E-value cutoff:
BDBM50209515
n/a
NameBDBM50209515
Synonyms:(R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6,7-difluoro-quinolin-4-ylamino]-propionic acid | CHEMBL245938
TypeSmall organic molecule
Emp. Form.C27H21F2N3O3
Mol. Mass.473.4707
SMILESCCOc1ccccc1-c1ccc(cc1)-c1nc2cc(F)c(F)cc2c(N[C@H](C)C(O)=O)c1C#N
Structure
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