| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Ligand | BDBM50209527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_455270 (CHEMBL886046) |
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| IC50 | 18±n/a nM |
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| Citation |  Cantin, LD; Magnuson, S; Gunn, D; Barucci, N; Breuhaus, M; Bullock, WH; Burke, J; Claus, TH; Daly, M; Decarr, L; Gore-Willse, A; Hoover-Litty, H; Kumarasinghe, ES; Li, Y; Liang, SX; Livingston, JN; Lowinger, T; Macdougall, M; Ogutu, HO; Olague, A; Ott-Morgan, R; Schoenleber, RW; Tersteegen, A; Wickens, P; Zhang, Z; Zhu, J; Zhu, L; Sweet, LJ PDE-10A inhibitors as insulin secretagogues. Bioorg Med Chem Lett17:2869-73 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE10A | PDE10_HUMAN | Phosphodiesterase 10 (PDE10) | Phosphodiesterase 10A |
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| Type: | Protein |
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| Mol. Mass.: | 88412.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y233 |
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| Residue: | 779 |
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| Sequence: | MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAP
KEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC
NNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLE
SGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVC
RGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELY
SDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYT
GYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHR
IRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIF
VYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTD
LERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNI
FSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMM
TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY
NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
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| BDBM50209527 |
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| n/a |
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| Name | BDBM50209527 |
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| Synonyms: | 4-[3-cyano-2-(2'-ethoxy-2-fluoro-biphenyl-4-yl)-6-fluoro-quinolin-4-ylamino]-butyric acid | CHEMBL245939 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H23F2N3O3 |
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| Mol. Mass. | 487.4973 |
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| SMILES | CCOc1ccccc1-c1ccc(cc1F)-c1nc2ccc(F)cc2c(NCCCC(O)=O)c1C#N |
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| Structure | 
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