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TargetBradykinin B1 receptor
LigandBDBM50209718
Substrate/Competitorn/a
Meas. Tech.ChEMBL_434361
IC50 9.6±n/a nM
Citation Biswas KLi AChen JJD'Amico DCFotsch CHan NHuman JLiu QNorman MHRiahi BYuan CSuzuki HMareska DAZhan JClarke DEToro AGroneberg RDBurgess LELester-Zeiner DBiddlecome GManning BHArik LDong HHuang MKamassah ALoeloff RSun HHsieh FYKumar GNg GYHungate RWAskew BCJohnson E Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides. J Med Chem 50:2200-12 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bradykinin B1 receptor
Name:Bradykinin B1 receptor
Synonyms:B1 BRADYKININ | B1 bradykinin receptor | B1R | BK-1 receptor
Type:Enzyme
Mol. Mass.:40508.87
Organism:Homo sapiens (Human)
Description:P46663
Residue:353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50209718
n/a
NameBDBM50209718
Synonyms:(R)-N-((R)-7-((tert-butylamino)methyl)chroman-4-yl)-3-(3,4-dichlorophenylsulfonamido)-3-(4-fluorophenyl)propanamide | CHEMBL390311
TypeSmall organic molecule
Emp. Form.C29H32Cl2FN3O4S
Mol. Mass.608.551
SMILESCC(C)(C)NCc1ccc2[C@@H](CCOc2c1)NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1
Structure
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