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TargetB1 bradykinin receptor
LigandBDBM50209720
Substrate/Competitorn/a
Meas. Tech.ChEMBL_434373 (CHEMBL919421)
Ki 151±n/a nM
Citation Biswas, KLi, AChen, JJD'Amico, DCFotsch, CHan, NHuman, JLiu, QNorman, MHRiahi, BYuan, CSuzuki, HMareska, DAZhan, JClarke, DEToro, AGroneberg, RDBurgess, LELester-Zeiner, DBiddlecome, GManning, BHArik, LDong, HHuang, MKamassah, ALoeloff, RSun, HHsieh, FYKumar, GNg, GYHungate, RWAskew, BCJohnson, E Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides. J Med Chem50:2200-12 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
B1 bradykinin receptor
Name:B1 bradykinin receptor
Synonyms:B1 BRADYKININ | B1R | B1bkr | BK-1 receptor | BKRB1_RAT | Bdkrb1 | Bkr | Bradykinin B1 receptor | KB1 | Kinin B1 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:38389.97
Organism:RAT
Description:B1 BRADYKININ BDKRB1 RAT::P97583
Residue:337
Sequence:
MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVITICFFGLLGNLLVLSF
FLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPFWAENIGNRFNWPFGTDLC
RVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRRRRQAQATCLLIWVAGGLLSI
PTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNVLGFLLPVTAIIFFNYHILASLR
GQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPYHFFAFLDFLVQVRVIQDCSWKEIT
DLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVLGTL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50209720
n/a
NameBDBM50209720
Synonyms:(R)-3-(4-fluorophenyl)-N-((R)-7-(pyrrolidin-1-ylmethyl)chroman-4-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)-propanamide | CHEMBL227600
TypeSmall organic molecule
Emp. Form.C30H31F4N3O4S
Mol. Mass.605.643
SMILESFc1ccc(cc1)[C@@H](CC(=O)N[C@@H]1CCOc2cc(CN3CCCC3)ccc12)NS(=O)(=O)c1cccc(c1)C(F)(F)F
Structure
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