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TargetB1 bradykinin receptor
LigandBDBM50209726
Substrate/Competitorn/a
Meas. Tech.ChEMBL_434373 (CHEMBL919421)
Ki 208±n/a nM
Citation Biswas, KLi, AChen, JJD'Amico, DCFotsch, CHan, NHuman, JLiu, QNorman, MHRiahi, BYuan, CSuzuki, HMareska, DAZhan, JClarke, DEToro, AGroneberg, RDBurgess, LELester-Zeiner, DBiddlecome, GManning, BHArik, LDong, HHuang, MKamassah, ALoeloff, RSun, HHsieh, FYKumar, GNg, GYHungate, RWAskew, BCJohnson, E Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides. J Med Chem50:2200-12 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
B1 bradykinin receptor
Name:B1 bradykinin receptor
Synonyms:B1 BRADYKININ | B1R | B1bkr | BK-1 receptor | BKRB1_RAT | Bdkrb1 | Bkr | Bradykinin B1 receptor | KB1 | Kinin B1 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:38389.97
Organism:RAT
Description:B1 BRADYKININ BDKRB1 RAT::P97583
Residue:337
Sequence:
MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVITICFFGLLGNLLVLSF
FLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPFWAENIGNRFNWPFGTDLC
RVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRRRRQAQATCLLIWVAGGLLSI
PTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNVLGFLLPVTAIIFFNYHILASLR
GQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPYHFFAFLDFLVQVRVIQDCSWKEIT
DLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVLGTL
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  Blast E-value cutoff:
BDBM50209726
n/a
NameBDBM50209726
Synonyms:(R)-3-(4-fluorophenyl)-N-((R)-7-((2-methoxyethylamino)methyl)chroman-4-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)-propanamide | CHEMBL227870
TypeSmall organic molecule
Emp. Form.C29H31F4N3O5S
Mol. Mass.609.632
SMILESCOCCNCc1ccc2[C@@H](CCOc2c1)NC(=O)C[C@@H](NS(=O)(=O)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1
Structure
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