| Reaction Details |
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 | Report a problem with these data |
| Target | Probable C-C chemokine receptor type 3 |
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| Ligand | BDBM50209974 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_458994 (CHEMBL926173) |
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| IC50 | 7±n/a nM |
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| Citation |  Pruitt, JR; Batt, DG; Wacker, DA; Bostrom, LL; Booker, SK; McLaughlin, E; Houghton, GC; Varnes, JG; Christ, DD; Covington, M; Das, AM; Davies, P; Graden, D; Kariv, I; Orlovsky, Y; Stowell, NC; Vaddi, KG; Wadman, EA; Welch, PK; Yeleswaram, S; Solomon, KA; Newton, RC; Decicco, CP; Carter, PH; Ko, SS CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity. Bioorg Med Chem Lett17:2992-7 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Probable C-C chemokine receptor type 3 |
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| Name: | Probable C-C chemokine receptor type 3 |
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| Synonyms: | C-C CKR-3 | C-C chemokine receptor type 3 | CC-CKR-3 | CCR-3 | CCR3_MOUSE | CD_antigen=CD193 | CKR3 | Ccr3 | Cmkbr1l2 | Cmkbr3 | MIP-1 alpha RL2 | Macrophage inflammatory protein 1-alpha receptor-like 2 | Probable C-C chemokine receptor type 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41791.57 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1445729 |
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| Residue: | 359 |
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| Sequence: | MAFNTDEIKTVVESFETTPYEYEWAPPCEKVRIKELGSWLLPPLYSLVFIIGLLGNMMVV
LILIKYRKLQIMTNIYLFNLAISDLLFLFTVPFWIHYVLWNEWGFGHYMCKMLSGFYYLA
LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFATITSIITWGLAGLAALPEFIFHESQD
SFGEFSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHK
AIRLIFVVMIVFFIFWTPYNLVLLFSAFHSTFLETSCQQSKHLDLAMQVTEVIAYTHCCI
NPVIYAFVGERFRKHLRLFFHRNVAVYLGKYIPFLPGEKMERTSSVSPSTGEQEISVVF
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| BDBM50209974 |
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| n/a |
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| Name | BDBM50209974 |
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| Synonyms: | 1-((3S,4S)-4-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)-1-acetylpiperidin-3-yl)-3-(5-acetyl-4-methylthiazol-2-yl)urea | CHEMBL249854 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36FN5O3S |
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| Mol. Mass. | 529.67 |
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| SMILES | CC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@@H](C1)NC(=O)Nc1nc(C)c(s1)C(C)=O |
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| Structure | 
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