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TargetC-C chemokine receptor type 3
LigandBDBM50209999
Substrate/Competitorn/a
Meas. Tech.ChEMBL_458974
IC50 1.2±n/a nM
Citation Pruitt JRBatt DGWacker DABostrom LLBooker SKMcLaughlin EHoughton GCVarnes JGChrist DDCovington MDas AMDavies PGraden DKariv IOrlovsky YStowell NCVaddi KGWadman EAWelch PKYeleswaram SSolomon KANewton RCDecicco CPCarter PHKo SS CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity. Bioorg Med Chem Lett 17:2992-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 3
Name:C-C chemokine receptor type 3
Synonyms:C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CD_antigen=CD193 | CKR3 | Eosinophil eotaxin receptor
Type:Enzyme
Mol. Mass.:41053.88
Organism:Homo sapiens (Human)
Description:P51677
Residue:355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50209999
n/a
NameBDBM50209999
Synonyms:1-(5-acetyl-4-methyl-thiazol-2-yl)-3-{(3S,4S)-4-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydro-1lambda*6*-thiophen-3-yl}-urea | CHEMBL249057
TypeSmall organic molecule
Emp. Form.C24H31FN4O4S2
Mol. Mass.522.656
SMILESCC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C
Structure
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