| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50210141 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_434482 (CHEMBL912072) |
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| Ki | 5.32±n/a nM |
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| Citation |  Liu, T; Kapustin, G; Etzkorn, FA Design and synthesis of a potent histone deacetylase inhibitor. J Med Chem50:2003-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50210141 |
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| n/a |
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| Name | BDBM50210141 |
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| Synonyms: | CHEMBL388195 | methyl (3S,6S,9S)-9-acetamido-6-[5-(hydroxycarbamoyl)pentyl]-5,8-dioxo-4,7-diazabicyclo[9.3.1]pentadeca-1(14),11(15),12-triene-3-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C23H32N4O7 |
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| Mol. Mass. | 476.5228 |
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| SMILES | COC(=O)[C@@H]1Cc2cccc(C[C@H](NC(C)=O)C(=O)N[C@@H](CCCCCC(=O)NO)C(=O)N1)c2 |
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| Structure | 
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