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TargetMacrophage inflammatory protein-1 alpha receptor
LigandBDBM50208999
Substrate/Competitorn/a
Meas. Tech.ChEMBL_444185 (CHEMBL892293)
IC50 59±n/a nM
Citation Xie, YFLake, KLigsay, KKomandla, MSircar, INagarajan, GLi, JXu, KParise, JSchneider, LHuang, DLiu, JDines, KSakurai, NBarbosa, MJack, R Structure-activity relationships of novel, highly potent, selective, and orally active CCR1 antagonists. Bioorg Med Chem Lett17:3367-72 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage inflammatory protein-1 alpha receptor
Name:Macrophage inflammatory protein-1 alpha receptor
Synonyms:C-C chemokine receptor type 1
Type:PROTEIN
Mol. Mass.:40846.87
Organism:Rattus norvegicus
Description:ChEMBL_1281523
Residue:355
Sequence:
MEISNITETYPTTTEYDYGDSTPCQKTDVRAFGAGLLPPLYSFVFIIGVVGNILVILVLM
QHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDNWVFGDAMCKLLSGFYYLGLYSE
IFFIILLTIDRYLAIVHAVFSLRARTVTFGIITSIIIWALAILASIPALCFFKAQWEFTH
HTCSPHFPDESLKTWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPNEKKAKAVRL
IFAITLLFFLLWTPYNLTVFVSAFQDVLFTNQCEQSKQLDLAIQVTEVIAYTHCCVNPII
YVFVGERFRKYLRQLFQRHVAIPLAKWLPFFSVDQLERTSSLTPSTGEHELSGGF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50208999
n/a
NameBDBM50208999
Synonyms:(R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea | (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea | BX-471 | BX-741 | CHEMBL232656
TypeSmall organic molecule
Emp. Form.C21H24ClFN4O3
Mol. Mass.434.892
SMILESC[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O |r|
Structure
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