| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen phosphorylase, liver form |
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| Ligand | BDBM50211286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_444271 (CHEMBL894512) |
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| Ki | 80000±n/a nM |
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| Citation |  Juhász, L; Docsa, T; Brunyászki, A; Gergely, P; Antus, S Synthesis and glycogen phosphorylase inhibitor activity of 2,3-dihydrobenzo[1,4]dioxin derivatives. Bioorg Med Chem15:4048-56 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen phosphorylase, liver form |
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| Name: | Glycogen phosphorylase, liver form |
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| Synonyms: | Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN |
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| Type: | Homodimer |
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| Mol. Mass.: | 97153.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Dimers associate into a tetramer to form the enzymatically active phosphorylase A. |
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| Residue: | 847 |
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| Sequence: | MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
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| BDBM50211286 |
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| n/a |
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| Name | BDBM50211286 |
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| Synonyms: | 5-[4-(6-bromo-2,3-dihydrobenzo[1,4]dioxin-2-ylmethoxy)-benzylidene]-thiazolidine-2,4-dione | CHEMBL243412 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14BrNO5S |
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| Mol. Mass. | 448.287 |
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| SMILES | OC1=NC(=O)C(S1)=Cc1ccc(OCC2COc3cc(Br)ccc3O2)cc1 |w:7.8,t:1| |
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| Structure | 
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