| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 9 |
|---|
| Ligand | BDBM50211428 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_455591 (CHEMBL886371) |
|---|
| IC50 | 5±n/a nM |
|---|
| Citation |  Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett17:3463-7 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 9 |
|---|
| Name: | Mitogen-activated protein kinase 9 |
|---|
| Synonyms: | JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48131.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
|---|
| Residue: | 424 |
|---|
| Sequence: | MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR
|
|
|
|---|
| BDBM50211428 |
|---|
| n/a |
|---|
| Name | BDBM50211428 |
|---|
| Synonyms: | CHEMBL245936 | N-ethyl-4-(4-(2-phenyl-1H-indol-3-yl)pyrimidin-2-ylamino)piperidine-1-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28N6O |
|---|
| Mol. Mass. | 440.5401 |
|---|
| SMILES | CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1c([nH]c2ccccc12)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
