| Reaction Details |
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 | Report a problem with these data |
| Target | Lysophosphatidic acid receptor 1 |
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| Ligand | BDBM50170859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_455638 (CHEMBL903636) |
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| IC50 | 160±n/a nM |
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| Citation |  Yamamoto, T; Fujita, K; Asari, S; Chiba, A; Kataba, Y; Ohsumi, K; Ohmuta, N; Iida, Y; Ijichi, C; Iwayama, S; Fukuchi, N; Shoji, M Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists. Bioorg Med Chem Lett17:3736-40 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysophosphatidic acid receptor 1 |
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| Name: | Lysophosphatidic acid receptor 1 |
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| Synonyms: | Edg2 | Gpcr91 | LPAR1_RAT | Lpa1 | Lpar1 | Lysophosphatidic acid receptor 1/lysophosphatidic acid receptor 3 | Lysophosphatidic acid receptor Edg-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41130.42 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_329844 |
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| Residue: | 364 |
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| Sequence: | MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVC
VFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSND
HSVV
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| BDBM50170859 |
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| n/a |
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| Name | BDBM50170859 |
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| Synonyms: | 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl)-3-methylisoxazol-5-yl)benzylthio)propanoic acid | 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonylamino)-3-methylisoxazol-5-yl)benzylthio)propanoic acid | 3-(4-{4-[1-(2-Chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-benzylsulfanyl)-propionic acid | CHEMBL361501 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23ClN2O5S |
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| Mol. Mass. | 474.957 |
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| SMILES | CC(OC(=O)Nc1c(C)noc1-c1ccc(CSCCC(O)=O)cc1)c1ccccc1Cl |
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| Structure | 
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