Reaction Details |
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Target | Cannabinoid receptor 1 |
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Ligand | BDBM50213468 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_456142 (CHEMBL888152) |
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Ki | 30±n/a nM |
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Citation | Ellsworth, BA; Wang, Y; Zhu, Y; Pendri, A; Gerritz, SW; Sun, C; Carlson, KE; Kang, L; Baska, RA; Yang, Y; Huang, Q; Burford, NT; Cullen, MJ; Johnghar, S; Behnia, K; Pelleymounter, MA; Washburn, WN; Ewing, WR Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series. Bioorg Med Chem Lett17:3978-82 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cannabinoid receptor 1 |
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Name: | Cannabinoid receptor 1 |
Synonyms: | Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52856.55 |
Organism: | Rattus norvegicus (rat) |
Description: | P20272 |
Residue: | 473 |
Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAI
AVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHV
FHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCL
MWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILW
KAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPL
LAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTA
QPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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BDBM50213468 |
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n/a |
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Name | BDBM50213468 |
Synonyms: | (S)-5,6-bis(4-chlorophenyl)-N-(1-hydroxy-4-methylpentan-2-yl)pyrazine-2-carboxamide | CHEMBL393837 |
Type | Small organic molecule |
Emp. Form. | C23H23Cl2N3O2 |
Mol. Mass. | 444.354 |
SMILES | CC(C)C[C@@H](CO)NC(=O)c1cnc(-c2ccc(Cl)cc2)c(n1)-c1ccc(Cl)cc1 |
Structure |
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