| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50213660 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_447479 (CHEMBL896502) |
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| Ki | 6.2±n/a nM |
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| Citation |  Chen, M; Guo, Z; Lanier, MC; Zhao, L; Betz, SF; Huang, CQ; Loweth, CJ; Ashweek, NJ; Liu, XJ; Struthers, RS; Bradbury, MJ; Behan, JW; Wen, J; O'Brien, Z; Saunders, J; Zhu, YF Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists. Bioorg Med Chem Lett17:3845-50 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37767.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1335047 |
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| Residue: | 327 |
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| Sequence: | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50213660 |
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| n/a |
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| Name | BDBM50213660 |
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| Synonyms: | (S)-1-(3-(1-(2-(4-(1H-tetrazol-5-yl)phenoxy)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone | CHEMBL394634 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H37F4N7O2 |
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| Mol. Mass. | 675.7183 |
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| SMILES | C[C@H](CNCCOc1ccc(cc1)-c1nnn[nH]1)c1c2CN(CCc2[nH]c1-c1cc(C)cc(C)c1)C(=O)Cc1c(F)cccc1C(F)(F)F |
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| Structure | 
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