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TargetGonadotropin-releasing hormone receptor
LigandBDBM50213663
Substrate/Competitorn/a
Meas. Tech.ChEMBL_447479
Ki 0.6±n/a nM
Citation Chen MGuo ZLanier MCZhao LBetz SFHuang CQLoweth CJAshweek NJLiu XJStruthers RSBradbury MJBehan JWWen JO'Brien ZSaunders JZhu YF Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists. Bioorg Med Chem Lett 17:3845-50 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gonadotropin-releasing hormone receptor
Name:Gonadotropin-releasing hormone receptor
Synonyms:GnRH receptor | GnRH-R
Type:PROTEIN
Mol. Mass.:37767.60
Organism:Rattus norvegicus
Description:ChEMBL_1335047
Residue:327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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  Blast E-value cutoff:
BDBM50213663
n/a
NameBDBM50213663
Synonyms:1-(3-((S)-1-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone | CHEMBL410547
TypeSmall organic molecule
Emp. Form.C35H36F4N8O
Mol. Mass.660.707
SMILESC[C@H](CNCCc1ccc(nc1)-c1nnn[nH]1)c1c2CN(CCc2[nH]c1-c1cc(C)cc(C)c1)C(=O)Cc1c(F)cccc1C(F)(F)F
Structure
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