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TargetChemokine receptor type 1 (CXCR1)
LigandBDBM50213736
Substrate/Competitorn/a
Meas. Tech.ChEMBL_447495
IC50 20000±n/a nM
Citation Wang YBusch-Petersen JWang FMa LFu WKerns JKJin JPalovich MRShen JKBurman MFoley JJSchmidt DBHunsberger GESarau HMWiddowson KL 3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists. Bioorg Med Chem Lett 17:3864-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Chemokine receptor type 1 (CXCR1)
Name:Interleukin-8 receptors, CXCR1/CXCR2
Synonyms:C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:Enzyme
Mol. Mass.:39803.83
Organism:Homo sapiens (Human)
Description:P25024
Residue:350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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  Blast E-value cutoff:
BDBM50213736
n/a
NameBDBM50213736
Synonyms:7-chloro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-dihydro-1lambda6-benzo[1,2,4]thiadiazin-5-ol | CHEMBL233346
TypeSmall organic molecule
Emp. Form.C19H14ClN3O4S
Mol. Mass.415.85
SMILESOc1cc(Cl)cc2c1N=C(Nc1ccccc1Oc1ccccc1)NS2(=O)=O |t:9|
Structure
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