| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-8 receptors, CXCR2 |
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| Ligand | BDBM50213742 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_447494 |
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| IC50 | >30000±n/a nM |
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| Citation |  Wang Y; Busch-Petersen J; Wang F; Ma L; Fu W; Kerns JK; Jin J; Palovich MR; Shen JK; Burman M; Foley JJ; Schmidt DB; Hunsberger GE; Sarau HM; Widdowson KL 3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists. Bioorg Med Chem Lett 17:3864-7 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-8 receptors, CXCR2 |
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| Name: | Interleukin-8 receptors, CXCR1/CXCR2 |
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| Synonyms: | C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | Interleukin-8 receptor B |
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| Type: | Protein |
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| Mol. Mass.: | 40767.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25025 |
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| Residue: | 360 |
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| Sequence: | MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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| BDBM50213742 |
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| n/a |
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| Name | BDBM50213742 |
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| Synonyms: | 2-(7-chloro-5-hydroxy-1,1-dioxo-1,4-dihydro-1lambda6-benzo[1,2,4]thiadiazin-3-ylamino)-benzoic acid | CHEMBL397809 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10ClN3O5S |
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| Mol. Mass. | 367.764 |
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| SMILES | OC(=O)c1ccccc1NC1=Nc2c(O)cc(Cl)cc2S(=O)(=O)N1 |t:11| |
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| Structure | 
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