Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBeta-1 adrenergic receptor
LigandBDBM50214224
Substrate/Competitorn/a
Meas. Tech.ChEMBL_456293 (CHEMBL888304)
Ki 420±n/a nM
Citation Washburn, WNHarper, TWWu, GGodfrey, JDMcCann, PGirotra, RShao, CZhang, HGavai, AMikkilineni, ADejneka, TAhmed, SCaringal, YHangeland, JZhang, MCheng, PTRussell, ADSkwish, SSlusarchyk, DAAllen, GTFrohlich, BHAbboa-Offei, BECap, MWaldron, TLGeorge, RJTesfamariam, BDickinson, KESeymour, AASher, PM Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations. Bioorg Med Chem Lett17:4290-6 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-1 adrenergic receptor
Name:Beta-1 adrenergic receptor
Synonyms:ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:51338.40
Organism:Homo sapiens (Human)
Description:P08588
Residue:477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50214224
n/a
NameBDBM50214224
Synonyms:CHEMBL398241 | N-(5-((R)-3-((S)-3-(3-chlorophenyl)-1-(3,4-dimethoxyphenyl)propylamino)-2-hydroxypropyl)-2-hydroxyphenyl)methanesulfonamide
TypeSmall organic molecule
Emp. Form.C27H33ClN2O6S
Mol. Mass.549.079
SMILESCOc1ccc(cc1OC)[C@H](CCc1cccc(Cl)c1)NC[C@H](O)Cc1ccc(O)c(NS(C)(=O)=O)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: