Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50214559 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_456344 (CHEMBL888355) |
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IC50 | 5±n/a nM |
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Citation | Tao, ZF; Li, G; Tong, Y; Chen, Z; Merta, P; Kovar, P; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors. Bioorg Med Chem Lett17:4308-15 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50214559 |
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n/a |
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Name | BDBM50214559 |
Synonyms: | 3-(4'-hydroxy-biphenyl-4-yl)-6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-ol | CHEMBL248200 | Chk1_130 |
Type | Small organic molecule |
Emp. Form. | C23H18N2O3 |
Mol. Mass. | 370.4006 |
SMILES | COc1cc2Cc3c(n[nH]c3-c2cc1O)-c1ccc(cc1)-c1ccc(O)cc1 |
Structure |
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