Reaction Details | |||
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Target | Gamma-aminobutyric acid receptor subunit beta-3 | ||
Ligand | BDBM50214673 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_448071 (CHEMBL898326) | ||
Ki | 2.5±n/a nM | ||
Citation | Alam, MS; Huang, J; Ozoe, F; Matsumura, F; Ozoe, Y Synthesis, 3D-QSAR, and docking studies of 1-phenyl-1H-1,2,3-triazoles as selective antagonists for beta3 over alpha1beta2gamma2 GABA receptors. Bioorg Med Chem15:5090-104 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Gamma-aminobutyric acid receptor subunit beta-3 | |||
Name: | Gamma-aminobutyric acid receptor subunit beta-3 | ||
Synonyms: | GABA A receptor alpha-4/beta-3/gamma-2 | GABA receptor beta-3 subunit | GABA-A receptor | GABRB3 | GBRB3_HUMAN | agonist GABA site | ||
Type: | PROTEIN | ||
Mol. Mass.: | 54130.51 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_448071 | ||
Residue: | 473 | ||
Sequence: |
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BDBM50214673 | |||
n/a | |||
Name | BDBM50214673 | ||
Synonyms: | 1-(2,6-dichloro-4-trifluoromethylphenyl)-5-hydroxymethyl-4-n-propyl-1H-1,2,3-triazole | CHEMBL395136 | ||
Type | Small organic molecule | ||
Emp. Form. | C13H12Cl2F3N3O | ||
Mol. Mass. | 354.155 | ||
SMILES | CCCc1nnn(c1CO)-c1c(Cl)cc(cc1Cl)C(F)(F)F |(3.18,-26.58,;1.93,-25.67,;2.1,-24.14,;.85,-23.23,;.86,-21.69,;-.61,-21.21,;-1.51,-22.46,;-.61,-23.7,;-1.09,-25.17,;-.06,-26.31,;-3.05,-22.45,;-3.81,-23.79,;-3.04,-25.12,;-5.35,-23.79,;-6.12,-22.45,;-5.35,-21.12,;-3.81,-21.12,;-3.04,-19.79,;-7.66,-22.45,;-9.22,-22.52,;-7.7,-20.91,;-7.61,-23.99,)| | ||
Structure |